PLAN2L: a web tool for integrated text mining and literature-based bioentity relation extraction

There is an increasing interest in using literature mining techniques to complement information extracted from annotation databases or generated by bioinformatics applications. Here we present PLAN2L, a web-based online search system that integrates text mining and information extraction techniques to access systematically information useful for analyzing genetic, cellular and molecular aspects of the plant model organism Arabidopsis thaliana. Our system facilitates a more efficient retrieval of information relevant to heterogeneous biological topics, from implications in biological relationships at the level of protein interactions and gene regulation, to sub-cellular locations of gene products and associations to cellular and developmental processes, i.e. cell cycle, flowering, root, leaf and seed development. Beyond single entities, also predefined pairs of entities can be provided as queries for which literature-derived relations together with textual evidences are returned. PLAN2L does not require registration and is freely accessible at http://zope.bioinfo.cnio.es/plan2l

Development of text mining tools for information retrieval from patents

Biomedical literature is composed of an ever increasing number of publications in natural language. Patents are a relevant fraction of those, being important sources of information due to all the curated data from the granting process. However, their unstructured data turns the search of information a challenging task. To surpass that, Biomedical text mining (BioTM) creates methodologies to search and structure that data. Several BioTM techniques can be applied to patents. From those, Information Retrieval is the process where relevant data is obtained from collections of documents. In this work, a patent pipeline was developed and integrated intoFEDER -Federación Española de Enfermedades Raras(NORTE-01-0145-FEDER-000004)info:eu-repo/semantics/publishedVersio

Automatic reconstruction of a bacterial regulatory network using Natural Language Processing

<p>Abstract</p> <p>Background</p> <p>Manual curation of biological databases, an expensive and labor-intensive process, is essential for high quality integrated data. In this paper we report the implementation of a state-of-the-art Natural Language Processing system that creates computer-readable networks of regulatory interactions directly from different collections of abstracts and full-text papers. Our major aim is to understand how automatic annotation using Text-Mining techniques can complement manual curation of biological databases. We implemented a rule-based system to generate networks from different sets of documents dealing with regulation in <it>Escherichia coli </it>K-12.</p> <p>Results</p> <p>Performance evaluation is based on the most comprehensive transcriptional regulation database for any organism, the manually-curated RegulonDB, 45% of which we were able to recreate automatically. From our automated analysis we were also able to find some new interactions from papers not already curated, or that were missed in the manual filtering and review of the literature. We also put forward a novel Regulatory Interaction Markup Language better suited than SBML for simultaneously representing data of interest for biologists and text miners.</p> <p>Conclusion</p> <p>Manual curation of the output of automatic processing of text is a good way to complement a more detailed review of the literature, either for validating the results of what has been already annotated, or for discovering facts and information that might have been overlooked at the triage or curation stages.</p

SR4GN: A Species Recognition Software Tool for Gene Normalization

As suggested in recent studies, species recognition and disambiguation is one of the most critical and challenging steps in many downstream text-mining applications such as the gene normalization task and protein-protein interaction extraction. We report SR4GN: an open source tool for species recognition and disambiguation in biomedical text. In addition to the species detection function in existing tools, SR4GN is optimized for the Gene Normalization task. As such it is developed to link detected species with corresponding gene mentions in a document. SR4GN achieves 85.42% in accuracy and compares favorably to the other state-of-the-art techniques in benchmark experiments. Finally, SR4GN is implemented as a standalone software tool, thus making it convenient and robust for use in many text-mining applications. SR4GN can be downloaded at: http://www.ncbi.nlm.nih.gov/CBBresearch/Lu/downloads/SR4G

Iniciativas de evaluación para la indización semántica de literatura médica en español: PLANTL, LILACS, IBECS Y BIOASQ

XVI Jornadas Nacionales de Información y Documentación en Ciencias de la Salud. Oviedo, 4-5 de abril de 2019El proyecto Faro de Sanidad del Plan de Impulso de las Tecnologías del Lenguaje (PlanTL) pretende fomentar el desarrollo de sistemas de procesamiento del lenguaje natural (PLN), minería de textos y traducción automática para español y lenguas cooficiales. Una actividad importante del PlanTL es la organización de campañas de evaluación de sistemas de PLN y minería de textos, un mecanismo que no sólo es clave para evaluar la calidad de los resultados obtenidos por sistemas y algoritmos predictivos, sino que representa un motor fundamental para fomentar el desarrollo de herramientas y recursos de tecnologías del lenguaje. Debido a la importancia de la literatura para la toma de decisiones en medicina y el volumen considerable de publicaciones en español, el Plan TL, en colaboración con el BSC, el CNIO, la BNCS y la iniciativa BioASQ ha lanzado una tarea competitiva relacionada con la indización automática de la literatura médica en español con términos DeCS. Su fin es generar recursos de etiquetado semántico que sirvan de ayuda a la indización manual. La tarea BioASQ (bioasq.org) de indización semántica biomédica en español se realizará usando resúmenes de artículos de revistas contenidas en las bases de datos LILACS (Literatura Lationamericana en Ciencias de la Salud) y IBECS1 (Índice Bibliográfico Español en Ciencias de la Salud) como conjunto básico etiquetado y, a partir de ellos, desarrollar los algoritmos de indización automática, facilitando así el desarrollo de modelos de inteligencia artificial. La evaluación de los sistemas se realiza con la plataforma de BioASQ, mediante un sistema de evaluación continua. En él, se solicita a los participantes que asignen automáticamente términos DeCS a los registros nuevos añadidos a las bases de datos a medida que se hacen públicos, y antes de que se haya completado la indización manual. El rendimiento de indización se calcula comparando indización automática y manual. Gracias a los resultados de ediciones previas de BioASQ para la indización de PubMed, se ha mejorado este proceso en dicho recurso. Esta tarea de indización biomédica en español servirá para generar recursos comparables para indizar LILACS e IBECS y otros conjuntos documentales.The health flagship project of the Plan for the Advancement of Language Technology (PlanTL) tries to promote the development of natural language processing systems (NLP), text mining and machine translation resources for Spanish and co-official languages. There is a growing demand for a better exploitation of datasets generated by clinicians, especially electronic health records, as well as the integration and management of this kind of data in personalized medicine platforms integrating also information extracted from the literature. In this context, the PlanTL collaborates in the organization of evaluation efforts of clinical NLP and text mining systems, a key mechanism to evaluate the quality of results obtained by such automated systems and a fundamental mechanism to promote the development of tools and resources related to language technologies. Given the importance of literature for medical decision-making and the growing volume of Spanish medical publications, the TL Plan, in collaboration with the BSC, CNIO, the Biblioteca Nacional de Ciencias de la Salud and the BioASQ team have launched a shared task on automatic indexing of abstracts in Spanish with DeCS terms. The aim of this tracks is to generate semantic annotation resources that can be used to assist manual indexing. The Spanish biomedical semantic indexing track of BioASQ (bioasq.org) will rely on abstracts of journals contained in the LILACS databases as a basic Gold Standard manually labeled benchmark set for the development of automatic indexing algorithms particularly those based on artificial intelligence language models. The evaluation of participating systems is done through the BioASQ platform, which requests results in a continuous evaluation process, i.e. automatically asking for DeCS term assignment for newly added documents to LILACS, as they are made public, and before the manual indexing results are publicly released. The indexing performance in BioASQ is calculated by comparing automatic indexing against manual annotations. Thanks to the results of previous editions of BioASQ for indexing PubMed, the MeSH indexing process of this resource was considerably improved. This novel effort on medical indexing in Spanish will serve to generate comparable resources to semantically index not only LILACS but also other health databases and repositories in Spanish.N

The Protein-Protein Interaction tasks of BioCreative III: classification/ranking of articles and linking bio-ontology concepts to full text

BACKGROUND: Determining usefulness of biomedical text mining systems requires realistic task definition and data selection criteria without artificial constraints, measuring performance aspects that go beyond traditional metrics. The BioCreative III Protein-Protein Interaction (PPI) tasks were motivated by such considerations, trying to address aspects including how the end user would oversee the generated output, for instance by providing ranked results, textual evidence for human interpretation or measuring time savings by using automated systems. Detecting articles describing complex biological events like PPIs was addressed in the Article Classification Task (ACT), where participants were asked to implement tools for detecting PPI-describing abstracts. Therefore the BCIII-ACT corpus was provided, which includes a training, development and test set of over 12,000 PPI relevant and non-relevant PubMed abstracts labeled manually by domain experts and recording also the human classification times. The Interaction Method Task (IMT) went beyond abstracts and required mining for associations between more than 3,500 full text articles and interaction detection method ontology concepts that had been applied to detect the PPIs reported in them.RESULTS:A total of 11 teams participated in at least one of the two PPI tasks (10 in ACT and 8 in the IMT) and a total of 62 persons were involved either as participants or in preparing data sets/evaluating these tasks. Per task, each team was allowed to submit five runs offline and another five online via the BioCreative Meta-Server. From the 52 runs submitted for the ACT, the highest Matthew's Correlation Coefficient (MCC) score measured was 0.55 at an accuracy of 89 and the best AUC iP/R was 68. Most ACT teams explored machine learning methods, some of them also used lexical resources like MeSH terms, PSI-MI concepts or particular lists of verbs and nouns, some integrated NER approaches. For the IMT, a total of 42 runs were evaluated by comparing systems against manually generated annotations done by curators from the BioGRID and MINT databases. The highest AUC iP/R achieved by any run was 53, the best MCC score 0.55. In case of competitive systems with an acceptable recall (above 35) the macro-averaged precision ranged between 50 and 80, with a maximum F-Score of 55. CONCLUSIONS: The results of the ACT task of BioCreative III indicate that classification of large unbalanced article collections reflecting the real class imbalance is still challenging. Nevertheless, text-mining tools that report ranked lists of relevant articles for manual selection can potentially reduce the time needed to identify half of the relevant articles to less than 1/4 of the time when compared to unranked results. Detecting associations between full text articles and interaction detection method PSI-MI terms (IMT) is more difficult than might be anticipated. This is due to the variability of method term mentions, errors resulting from pre-processing of articles provided as PDF files, and the heterogeneity and different granularity of method term concepts encountered in the ontology. However, combining the sophisticated techniques developed by the participants with supporting evidence strings derived from the articles for human interpretation could result in practical modules for biological annotation workflows